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Leptin is released from adipose tissue in proportion to the amount of adipose and acts centrally to suppress food intake and increase metabolic rate

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Some research has shown that cells exposed to e-cigarette vapor showed similar genetic changes as cells exposed to conventional cigarette smoke raising concerns that e-cigarettes could potentially lead to lung cancer

However, compared to traditional cigarettes, heated tobacco products are designed to heat the tobacco rather than burn it, which can result in lower levels of tar and other harmful chemicals.