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The regulatory effect of 7 nAChR on the action of immune factors MCP-1 and KC has been confirmed in stearic acid (C18:0) or TNF--induced 3T3-L1 adipocytes (Jiao et al., 2016) and 7 nAChR / deficient mice (Wang et al., 2011)

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Notably, IL-31RA expression is regulated by STAT3 and may persist even after the resolution of inflammation, suggesting the existence of a neuronal itch memory (99, 100)

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