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Now, we observed a downregulation in the mRNA levels of the other two Nrf2 targets, Nqo1 and Hmox1 , thus suggesting that aspartame can reduce Nrf2 activity and, therefore, increase lipid peroxidation due to a reduction in the Nrf2-related antioxidant defense in mouse liver

Acknowledgements Funded in part by grants R37 (MH48404), R01 (MH084906), Pittsburgh Life Sciences Greenhouse (Bita Moghaddam), and R01DA03383 and P50 MH086385 (Daniel Javitt)

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doi: 10.3390/ijms21217877