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As Figure 2 shows, the wholesale cost is the average manufacturer price plus the wholesale markup, which is the amount tobacco distributors add to the cost of the product to cover their expenses and generate a profit

Comparing tax rates for other tobacco products is difficult as some states levy a per-unit rate, and others take a percentage of wholesale or manufacturer prices

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It will not be suited to every smoker

The integrin CD 11b/CD 18 was greater in smokers monocytes, which increased monocyte adherence to HUVECs in culture