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In the brain, liraglutide concentrations were the highest in the hypothalamus, followed by the cerebellum and cerebrum

Agents such as dulaglutide, liraglutide, semaglutide, and tirzepatide differ in pharmacology and dosing, directly influencing perioperative safety, particularly due to their effects on gastric motility and the high frequency of gastrointestinal (GI) adverse events that raise concerns about aspiration and postoperative morbidity in urgent or elective procedures

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GLP-1 medications including semaglutide can trigger gout flares in some patients due to rapid weight loss and uric acid elevation

Expert UK guidance on GLP-1 therapy and fibroid health.