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Oxidative stress-induced apoptosis and autophagy: Balancing the contrary forces in spermatogenesis

HepG2 cells can be killed by indolizine derivatives, which promoted p53 activation and increased its accumulation in nuclei 147

Furthermore, as cisplatin and radiationbased treatment are likely to further select for tumors with extremely high levels of activation[18, 19, 23], ICI-based rescue of conventional treatment failure, or potentiation of conventional chemoradiation strategies may very well be unfeasible at least in a subset of HNSCC [56]

Baugh, E

Increased p53 can bind to the Plzf promoter and negatively regulate Plzf , leading to a reduction in Plzf expression and the number of Plzf + SSCs in mouse testes, resulting in a decrease in male fertility ( TP53 transcription and promoting the ubiquitination and degradation of p53 in several cell lines ( Csnk1a1 , the gene encoded Casein kinase I isoform alpha (CKI-), knockout accelerated nuclear p53 protein expression by disrupting Mdm2-mediated p53 ubiquitination in mouse spermatogonia

& Gu, W