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We thank George Brown, John Villajin, Louisa Green, Asha Mathews, Chifundo Stubbs, Olabisi Awogbemila, Noah Yogo, Elka Giemza, Stephanie David, Adebukola Shopade, and Herman Rocha of the NIHR Wellcome Trust Clinical Research Facility for supporting this study

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The majority of studies that have been carried out to analyze the efficacy of pharmacotherapies to aid tobacco cessation have studied smokers of 15 or more cigarettes per day.1,6,8-15,33,34,44-50 There is no clear indication for the use of these products by smokers of less than 10 cigarettes per day, although the decision should always be made taking into account the patient's health status and preferences, and in such cases the decision to use a pharmacological treatment is optional

However under the current trade environment a domestic inclusion regulation may be possible to protect US farmers from the unintended consequences of the double duty drawback

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