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In contrast, the p53 / Rb1 double knockout model with Cre-activated mutant Myc T58A that leads to stabilised MYC proteins, is representative of the variant subtype of human SCLC [149]
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Chronic viral infections promote hepatoma cells transformation by inducing MDM2p53 axis dysfunction To promote themselves long-term survival in the host, viruses have lots of ways to interfere with the defense mechanisms of hepatocytes and immunity system, such as upregulating virus-receptor expression, changing hepatocytes metabolic pathways, and inducing hepatic T-cell exhaustion 40

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