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Keywords: tobacco smoke, carcinogens, DNA adducts, nicotine Introduction The new century has witnessed a continuing decrease in age-adjusted lung cancer mortality in the United States, from 55.4 per 100,000 persons in 1999 to 50.7 in 2007, the most recent year for which data are available ( This encouraging positive trend, which has resulted almost entirely from decreased cigarette smoking, illustrates the power of cancer prevention

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Countries with official tobacco endgame goals showed significantly higher implementation scores