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These products are not subject to F.D.A.s premarket review or approval requirements for safety and effectiveness, the F.D.A

However, epidemiological studies showed a dose-dependent effect of smoking on BP 2,6 , even if a meta-analysis highlighted no causal association between BP and smoking heaviness in current smokers 4

This factsheet was produced in March 2020 and updated in February 2024 For further information, read the European Respiratory Societys position statement on novel products and harm reduction:

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Smoking 11 to 15 cigarettes a day conferred an 84% higher risk of cardiovascular disease and more than twice the risk of death from all causes

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