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42% of patients reported modifying their vape devices to enhance battery life or smoke production, increasing the risk of malfunctions

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The vape pod is heated through battery-operated coils which contain an e-liquid with 5% nicotine by weight

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Studies of this phenomenon have shown that macrophages are activated by factors such as cigarette smoke extracts and release inflammatory mediators such as TNF-, CXCL1, CXCL8, CCL2, leukotriene (LT) B4 and reactive oxygen species (ROS), etc., which mediate the inflammatory response ( Figure 2 Macrophages have different phenotypes with different activation pathways that lead to different organismal responses