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The studies analyzed consistently highlight adolescence as a critical period of neurobiological maturationparticularly within the prefrontal cortex and limbic regions that regulate cognition, emotion, and decision-makingduring which nicotine exposure may confer heightened vulnerability ( Nicotine acts on nicotinic acetylcholine receptors, affecting neurotransmission and synaptic plasticity

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doi: 10.1186/s12954-022-00630-8 [DOI] [PMC free article] [PubMed] [Google Scholar] 43.Kozak Z, Ciccarone D, Thrul J, Cole TO, Pappas AL, Greenblatt AD, et al