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Indeed, one of the limitations of the study was that human cells are not exposed to e-liquids per se, but rather to the aerosols where the concentrations are lower [86]

In the human body, approximately 7080% of the absorbed nicotine is metabolized into cotinine in the liver by cytochrome P450 2A6 18

The first cases of acute lung damage linked to the use of electronic cigarettes started to show up in the USA in April 2019