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Global Adult Tobacco Survey (GATS) India, 2009-2010

Additional evidence on harms from e-cigarette use (whether used for tobacco cessation or not) considered by the USPSTF included data of the 2019 EVALI outbreak in the US 53 and the 2018 report Public Health Consequences of E-Cigarettes by the National Academies of Sciences, Engineering, and Medicine

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Conversely, reduced expression of the antioxidant transcription factor nuclear factor E2-related factor 2 (Nrf2) due to DNA hypermethylation in COPD, may increase the susceptibility of bronchial epithelial cells to oxidative stress-dependent cell death (181)
