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And that's when we meet the "Worm Guys." Agent J looks on, stunned, as K talks to the quartet of sarcastic, squirmy little dudes who smoke cigarettes, trade gossip, and spill coffee

Through this integrated in vivo and organoid-guided approach, our study aims to unravel how chronic smoke exposure disrupts lung stem cell function and regenerative capacity, providing deeper mechanistic insights into COPD progression and highlighting potential cellular and molecular targets for regenerative therapy