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In 2019, the FDA had authorized IQOS and handful of other Marlboro HeatSticks through its premarket tobacco product application process (PMTA), in which PMI had to demonstrate that these products would be appropriate for the protection of public healthmeaning, in short, that theyd be more likely to help adults who smoke switch to the safer alternative than to introduce a new generation to nicotine

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An analysis of 11 major international clinical trials that included 942 subjects found that some women experienced the following side effects: Headache Weight gain Acne Breast pain Abdominal pain Irregular periods Amenorrhea (no periods for a few to several months) Prolonged periods Please contact your doctor if you experience any of the above complaints

Heliyon 6 , e04530 (2020)

Qian W, Kong X, Zhang T, et al