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Murty R

J.s 2015 study, The role of mesoaccumbens dopamine in nicotine dependence reports that nicotine, one of the chemicals found in tobacco, is the primary cause of tobacco addiction

For example, PMI claims it is producing smoke-free products that are a better choice for smokers than continued cigarette smoking and can benefit public health. This framing ignores decades of successful tobacco control policies, such as taxation, marketing restrictions and smoke-free laws, that have helped millions quit smoking

doi: 10.1007/s00412-002-0227-z

The potential is the entire global population who is currently consuming nicotine (mainly cigarettes)

Studies have highlighted the impact of nicotine on sperm DNA methylation, indicating variable methylation levels at specific genetic loci or CpG islands leading to potential adverse health outcomes in offspring, such as increased spontaneous locomotor activity and attention deficits by altering methylation levels in the promoter of Dat 20,21,22