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this represents 0.5 percent of people who had not previously used smokeless tobacco (i.e., those at risk for initiation)

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Clin Pharmacol Transl Med 1, 1419

In 1964, the surgeon generals report came out

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[83] Carbon monoxide exposure has been implicated in the process of atherosclerosis, contributing to the accumulation of cholesterol in the aorta and coronary arteries
