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Since no significant differences were found between the first and second 100-puff block, it was decided to analyze only the first 100 puffs in the present study

Using a statistical approach known as mediation analysis, the researchers determined the sequence of events: genetic predisposition leads to smoking, which leads to decreased brain volume

Smoking hardens the gums and restricts blood flow which can make gums less capable of fending off oral bacteria invasion

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