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Although not previously explored in the context of LCNS, some of these endogenous signatures have been tied to propensity for metastasis and preferential response to different therapies, so further research in this area may provide valuable guidance to LCNS management

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For alkoxydiazeniums of form 9 (a subset of 6 ), some reactions are proposed to begin with deprotonation of the -position, giving zwitterion 10 (Scheme 5), which behaves as structures 10b or 10c in subsequent reactions

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JAMA Neurology, 71 , 284290

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