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In 1967, the Germans were the first to examine the relationship between nicotine and gastrointestinal disease after observing an increase in peptic ulcers in rats due to nicotine's increased gastric juice output

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It has been observed that children exposed to secondhand smoke have a significantly higher incidence of metabolic syndrome, at 19.6%, compared to 5.6% in non-exposed children

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doi:10.3390/toxics6030043

Mechanisms and effects of immunomodulation by cigarette smoke