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Figure 2 Sensory cooling activity of Newport non-menthol cigarettes introduced in California in 2023 and 2025, compared to Newport menthol cigarettes Chemical analysis revealed that none of the Newport non-menthol varieties introduced in 2025 contained any of the major commercial cooling agents over the limits of detection, while the WS-3 content of Newport non-menthol green cigarettes marketed in 2023 was 1.26 0.05 mg/cig, similar to our previously reported findings 3

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Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1