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Since substance use disorders decrease medication adherence in clients, it is crucial to consider the association between antipsychotics and substance abuse treatments that might act synergistically in clients with dual diagnoses (Dervaux, 2020)

Interestingly, caffeine is also metabolized by CYP1A2, and studies have found smoking increases caffeine clearance by inducing CYP1A2 activity, as it does with clozapine and olanzapine [42]

Funding This work was supported by a grant from Bloomberg Philanthropies

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