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Availability of data and materials The dataset used and analysed during the current study are available from the corresponding author on reasonable request

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While the speed of nicotine absorption from Pulze+iD is comparable to cigarettes, the peak nicotine level and overall nicotine exposures (referred to as Area under Curve, or AUC) are lower indicating the system has a lower dependency potential compared to cigarettes

Among women, this share was 5.0 % or higher in just four of the Member States

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While the exact cause of these headaches is not fully understood, it is believed to be related to the presence of Naloxone, one of the active ingredients in Suboxone