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The 42 receptors show exceptionally high affinity for nicotine, featuring unique structural characteristics including cation- interactions and strong hydrogen bonds

In this line, results from GCMS and HPLC analyses indicated that cinnamaldehyde (CAD) and 2-methoxycinnamaldehyde, but not dipropylene glycol or vanillin, were mainly responsible for the high cytotoxicity of cinnamon-flavoured e-liquids [80]

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They point to the fact that, to date, marketing for IQOS has appeared at music festivals and film festivals in Europe, Asia and South America, alongside high profile partnerships with streetwear brands and fashion designers