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Effects of cigarette smoke on immune response: chronic exposure to cigarette smoke impairs antigen-mediated signaling in T cells and depletes IP3-sensitive Ca(2+) stores

Physical changes caused by nicotine Nicotine can also cause physical changes in the brain, some temporary, and others that some researchers, like Picciotto, worry could be long-lasting

The past offers comfort but may also prevent movement toward a different future

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Respiratory Medicine, 4(2), 116128

Smoking exposes the body to harmful toxins and heavy metals such as nicotine, nitric oxide (NO), and lead (Pb), whose effects may be enhanced by genetic vulnerability like the APOE4 allele