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Although creatine is primarily recognized for its muscle-enhancing properties, including promoting protein synthesis and supporting cell hydration by increasing water intake in muscle cells ( However, our findings differ from studies suggesting that creatine intake may alleviate gastrointestinal discomfort, including diarrhea, in conditions like IBD ( An unexpected finding in our study is that creatine intake appears to have a significant protective effect on constipation in men and younger participants, but no similar association was found for chronic diarrhea

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