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Table 3: Common Treatment Emergent AEs (%) in the Fixed-Dose, Placebo- Controlled Studies (HLGTs 5% of patients in the 1 mg BID CHANTIX Group and more commonly than Placebo and PT 1% in the 1 mg BID CHANTIX Group, and 1 mg BID CHANTIX at least 0.5% more than Placebo) The overall pattern and frequency of adverse events during the longer-term premarketing trials was similar to those described in Table 3, though several of the most common events were reported by a greater proportion of patients with long-term use (e.g., nausea was reported in 40% of patients treated with CHANTIX 1 mg twice daily in a one year study, compared to 8% of placebo-treated patients)

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Nicotine vaping in England: an evidence update including health risks and perceptions, 2022: A report commissioned by the Office for Health Improvement and Disparities

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The randomised controlled trial of 1,140 pregnant women at 24 hospitals in the UK compared vaping a refillable vaping device (n=569) to nicotine patches (n=571)