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An opioid overdose is characterized by Decreased consciousness, somnolence Small pupils Fatigue Slow speech Calmness Cold sensation Anesthesia Coma Urinary retention Respiratory depression, respiratory failure Hypoxia, cyanosis, grayish pale skin Bradycardia Hypotension Circulatory collapse Life-threatening overdose can occur after injection as well as smoking but is much more common after injections

After an average of 7.5 s (78 s) of stimulus presentation, participants were automatically prompted via headphones to rate their momentary state of pleasure, arousal, and craving to smoke (T1)

When you are breathing in cigarette smoke, it irritates the vocal cords

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IQOS heated tobacco products are not alternatives to quitting and are not designed as cessation aids