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Smokings Achilles heel demystified: Triggering persistent adaptive immunity by variability responses to immunogens

The relevance of these results lies in the potential for disruption of mitochondrial structure and functionality to permit cytosolic Ca 2+ to remain elevated with nicotine exposure, leading to long-term downstream genomic and nongenomic changes in ASM that overall contribute to airway hyperreactivity and remodeling

2016 Aug 1;139(3):613-6

Margaglione, M

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