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Contact your GP within 2448 hours if you experience: Persistent vomiting that prevents adequate fluid or medication intake Severe abdominal pain , particularly if localised to the upper right quadrant or radiating to the back Signs of dehydration : reduced urination, dark urine, dizziness, or dry mucous membranes Unexplained weight loss beyond expected therapeutic effect Jaundice (yellowing of skin or eyes), which may indicate gallbladder or liver complications Changes in bowel habit lasting more than one week, including persistent diarrhoea or constipation Symptoms of thyroid concerns : persistent neck lump, hoarseness, or difficulty swallowing (though extremely rare) Seek immediate medical attention (999 or A&E) if you develop: Severe, sudden-onset abdominal pain that is constant and worsening Signs of pancreatitis : severe upper abdominal pain radiating to the back, accompanied by nausea and vomiting (stop taking Saxenda immediately) Allergic reactions : facial swelling, difficulty breathing, or widespread rash If you cannot reach your GP and need advice, contact NHS 111 for guidance