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Judith Zarek MSc, PhD is a Knowledge Mobilization Specialist with First Exposure

Limitations, Reasons for Caution Overall, recommendations are strengthened and evidence is improved, but remain generally low to moderate quality

Second, payer policies may continue to shape access even after lower-cost versions become available

Airway and Aspiration Risk Delayed gastric emptying has important implications for airway management

OTC drugs, while currently a smaller segment, are emerging as a significant growth frontier due to increasing consumer empowerment and digital accessibility

Future Directions Although the striking cardiometabolic benefits of GLP-1 RAs in T2DM are well-established, there is evidence that prescribing rates around the world have been suboptimal