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Cardiovascular and metabolic disease risk factors often emerge early, with childhood obesity accelerating their progression [3]

Ischaemia on electrocardiogram was defined as any of Minnesota codes 1.1-1.3, 4.1-4.4, 5.1-5.3 and 7[17]

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The authors found that, on average, smoking a pack of cigarettes a day led to 150 mutations in each lung cell every year

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