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Mutational landscape of gingivo-buccal oral squamous cell carcinoma reveals new recurrently-mutated genes and molecular subgroups

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Specifically, it has been reported that stimulation of tumor -adrenergic receptors increases the production of several factors that promote metastasis, including vascular endothelial growth factor (VEGF), matrix metalloproteinases (MMP-2 and MMP-9), and pro-inflammatory cytokines such as IL-6 and IL-8 (Cole et al., 2015

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