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[7] Individual metabolic rates: Genetic differences among individuals, especially in the enzyme CYP2A6, greatly impact how quickly nicotine is metabolized in their bodies

At least two reviewers independently screened each title and abstract, followed by full texts of the remaining articles in accordance with the inclusion and exclusion criteria

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In addition, a variety of substances that are known to be toxic, carcinogenic, or disease-causing have been identified in vaping liquid solutions and aerosols, including delivery solvents, flavorings, carbonyl compounds, minor tobacco alkaloids, tobacco-specific nitrosamines, reactive oxygen species, metals, and other toxicants

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