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[26] Researchers are part of the conflict, with some opposing and others supporting of e-cigarette use

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No statistically significant differences were found between users and non-users of bupropion, cytisine, or NRT, with respect to nicotine dependence levels, treatment completion rates, reasons for treatment discontinuation, or the frequency of treatment-related adverse effects

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(Recreational use and sale of cannabis in Canada was legalized starting in 2018)