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Tobacco filler was removed from each cigarette, which were stored at 20 C prior to measurement and conditioned in a CSH-111 stability test chamber (ESPEC Corp., Osaka, Japan) at 22 1 C and 60 2% humidity for at least 48 h, as specified in ISO 3402 [19]

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When to Contact Your Doctor About Nicotine Interactions Seek medical advice if you experience any of the following while using nicotine products: Sudden mood swings or worsening depression Unexplained bleeding or bruising Rapid or irregular heartbeat Severe headaches or dizziness Increased anxiety or insomnia despite medication Early consultation can prevent serious complications and help tailor your treatment safely