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Dong, Z., Birrer, M

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Studies have found that MMP14 activity and protein was increased in the airway epithelium of tobacco smoke-exposed mice and decreased MMP14 activity and protein could diminish the mucin 5AC, oligomeric mucus/gel-forming (MUC5AC) transcripts that played significant roles in the development of COPD [104]

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For a daily smoker, these receptors are often hypersensitive after a long night spent without nicotine