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Polycyclic aromatic hydrocarbons contained in Cigarette smoke increase the activity of CYP 1A2 enzymes, and thus affects the metabolism of its substrates, several antipsychotics, e.g., olanzapine, haloperidol, clozapine, as well as some antidepressants (amitriptyline, clomipramine, doxepin, duloxetine, fluvoxamine, imipramine, mianserin, mirtazapine) and benzodiazepines (64)

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