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One possible explanation provided by gene expression data in 2024 suggests that smoking is significantly associated with the upregulation of the cytokine receptor-like factor-1 (CRLF1) gene, which translates to actin alpha 2 (ACTA2+) smooth muscle cells, particularly found in carotid plaques

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Over time, the smokers brain develops less of a response to nicotine due to the high concentrations

Studies suggest that e-liquid substances such as aldehydes and flavorings may damage the eyes' tear film and lead to inflammation, worsening of the sight and reduced blood flow to the eye, according to the article

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