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Cigarette smoking is a major risk factor for the development of coronary heart disease (CHD), with male cigarette smokers running a twofold risk of dying from CHD compared to nonsmokers

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For instance, 2 large meta-analyses were unable to depict an effect of smoking status on response to infliximab [22,23], and smoking, if anything, may have a positive impact on thiopurine metabolism and related treatment response

In most cases, they may lie motionless and experience an altered sense of time

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So the nicotine stains are probably really set in the fabrics