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The mainstream smoke of the herbal cigarette contained no detectable levels of tobacco-specific nitrosamines or nicotine, while carbon monoxide and benzo()pyrene contents were higher in the herbal cigarette than in the general cigarette, as were phenolic contents such as hydroquinone, resorcinol, and catechol, albeit with a lower cresol level

Among these, tobacco-specific nitrosamines (such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N -nitrosonornicotine (NNN)), polycyclic aromatic hydrocarbons (such as benzo[ a ]pyrene) and aromatic amines (such as 4-aminobiphenyl) seem to have an important role as causes of cancer

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Physicians should also consider changing the way they inquire about smoking because the number of packs someone smokes per year is not necessarily predictive of long-term health risks, they said