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In addition, p53 also plays an important role in anti-tumour immunity through the regulation of innate and adaptive immune profiles [174] and/or the expression of immune-inhibitory checkpoint regulators by the cancer cells [175]

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However, in opposition to this proposed mechanism, adolescents with slower nicotine metabolism actually smoke more cigarettes per day and exhibit higher nicotine dependence [62,68]

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Proportional sampling methods were used again to select two manzanas within each selected AGEB, with a target of seven interviews per manzana