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The team applied a diagnostic approach called Mendelian randomization

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Smokers with a smoking-related chronic disease or SMI and who have no intention of stopping immediately or seeking cessation support will be randomised to one of two groups, if they decline referral to NHS stop smoking services (SSS) and smoking cessation medication: an intervention group offered encouragement by their practitioner to use an e-cigarette, or a standard care control group who will receive nothing beyond the usual care already provided prior to randomisation

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