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European Respiratory Review

We hypothesized that Bacillaceae isolates would activate innate immune pathways, with stronger NF-B activation expected given its role in antibacterial inflammation, and that heat-killing would reduce activation by disrupting heat-sensitive bacterial components

Conclusions Collectively, these findings emphasize brain regions (e.g., ventromedial PFC, insula, thalamus) critically linked with cigarette smoking, suggest neuroimaging paradigms warranting additional consideration among smokers (e.g., pain processing), and highlight regions in need of further elucidation in addiction (e.g., cerebellum)

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