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Activated epithelial cells and innate immune cells also release pro-remodelling factors, such as epidermal growth factor receptor (EGFR) ligands, and transforming growth factor (TGF)- , which trigger goblet cell hyperplasia, EMT, fibroblast activation, and airway smooth muscle cell proliferation and hypertrophy (1, 2)

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Airway epithelial barrier dysfunction in chronic obstructive pulmonary disease: role of cigarette smoke exposure

Cigarette addiction feeds on habit, but quitting restores strength and control

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