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[DOI] [PubMed] [Google Scholar] Hua X, Sun DY, Zhang WJ, Fu JT, Tong J, Sun SJ, et al

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However, it exhibits low cell membrane permeability and demonstrates substantial toxicity in animal models, thereby constraining its potential application as a therapeutic agent (Zweygarth et al., 1986)

It is important to note that when fat cells grow larger, they release nicotinamide N-methyltransferase (NNMT), which slows down metabolism and further leads to weight gain