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The benefits of adding NRT to BUP appear to be limited.(6) More recently, research has examined the combination of NRT with varenicline.(7-10) Of the three controlled clinical trials, two reported no benefit of adding the nicotine patch to varenicline for long-term abstinence(8, 10) while one substantially larger study did find evidence favoring the CP.(9) The potential for improving abstinence rates through non-nicotine CPs, with different mechanisms of action is plausible but not well studied.(11-13) Two studies compared the combination of BUP and varenicline to varenicline alone, with encouraging findings for the CP, specifically among heavy smokers.(12, 13) The combination of BUP and naltrexone (NTX) was initially proposed for smoking cessation in weight-concerned(14) and overweight or obese smokers,(15) based on the weight-suppressant effects of NTX

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