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Animals and tobacco smoke Direct exposure in experimental settings [edit] The first recorded attempts to artificially induce animal tumors through the application of tobacco products occurred in 1911

80 : 925931 Gammon M, Schoenberg J, Ahsan H, Risch H, Vaughan T, Chow W, Rotterdam H, West A, Dubrow R, Stanford J, Mayne S, Farrow D, Niwa S, Blot W, Fraumeni Jr J

Yun JE, Kimm H, Choi YJ, et al

Evidence suggests tobacco was growing in North America by 6,000 BCE, and smoking tobacco leaves may have been practiced on the continent for 2,300 years

After the London Company lost its charter, the pattern of indentured servant immigration expanded and Virginia became more profitable

Predicting young adulthood smoking among adolescent smokers and nonsmokers