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Influential public health research such as the Cochrane Review 2022 have widely agreed that heated tobacco products expose users to lower levels of key toxins and carcinogens than are otherwise found in combustible tobacco smoke

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(ISBN 978-92-2-213425-0, lire en ligne) Malson, J.L., Lee, E.M., Moolchan, E.T., Pickworth, W.B., "Nicotine delivery from smoking bidis and an additive-free cigarette", Nicotine and Tobacco Research (2002) 4:485-490

Validation of the 3D reconstructed human skin micronucleus (RSMN) assay: An animal-free alternative for following-up positive results from standard in vitro genotoxicity assays